Car T

Adoptive transfer of t cells expressing cars is a promising anti cancer therapeutic because car modified t cells can be engineered to target virtually any tumor associated antigen.

Car t. Car t cell therapies are sometimes talked about as a type of gene or cell therapy or immune effect cell therapy. Chimeric antigen receptor car t cell therapy involves genetic modification of patient s autologous t cells to express a car specific for a tumor antigen following by ex vivo cell expansion and re infusion back to the patient. The immune system recognizes foreign substances in the body by finding proteins called antigens on the surface of those cells. Once the collected t cells have been engineered to express the antigen specific car they are expanded in the laboratory into the hundreds of millions.

These then target the cancer cells. Car t cell therapy is a type of immunotherapy. The car t cell therapies furthest along in development target an antigen found on b cells called cd19 see the box below titled the making of a car t cell. Car t cell therapy is a very complex and specialist treatment.

Cars are fusion proteins of a selected single chain fragment variable from a specific monoclonal antibody. Improving time to treatment with car t cell therapy is an area of significant development adds shaughnessy. With this treatment a specialist collects and makes a small change to your t cells. How car t cell therapy works immune receptors and foreign antigens.